Disabling the Front Row shortcut!
There is one shortcut that I find annoying in Mac OS X and it is the Front Row shortcut. The reason why I hate it is because I often accidentally set it off and it makes my Mac feel unresponsive for a few seconds until Front Row appears. It is possible to disable the "Command - Esc" shortcut however. It is done by unchecking the "Hide and Show Front Row" shortcut in the Keyboards Shortcuts section of System Preferences. What is great is that even if you disable the shortcut, you can still load Front Row with the Apple Remote or by directly loading the application from the Applications folder (you can also add the Front Row icon to the Dock).